《2010年新药研发立项与专利策略专题培训教材(全英文)》(100页).rar The　need　for　NMB　reversal ＆＃8226；　To　speed　up　recovery　from　neuromuscular　block　at　the　end　of　surgery　or intensive　care –　＞65%　of　elective　surgery　was　performed　as　day　procedures　in　the　UK and　＞70%　in　the　USA –　Hospital　cost:　$1,237/day　for　all　medical　conditions　＆　$2,401/day　in an　ICU　(USA　2005).　USA　2000　expenditure　for　critical　care　medicine ~$15-55　billion　(or　~0.5%　of　GDP　＆　~13%　of　national　health　care expenditure) ＆＃8226；　To　prevent　residual　neuromuscular　block　and　post-operative complications –　Incidence　of　residual　paralysis:　~38%　surgical　outpatients　＆　47% inpatients –　Incidence　of　post-operative　complications:　~5%　of　all　patients,　up　to 65%　in　older　patients,　of　which　19%　life-threatening　(e.g.　pulmonary complications)